Interferon V Regulates Antigen - induced Eosinophil Recruitment into the Mouse Airways by Inhibiting the Infiltration of CD 4 + T Cells

We have previously shown that antigen-induced eosinophil recruitment into the tissue of sensitized mice is mediated by CD4 + T cells and interleukin 5. To determine whether interferon 3' (IFN-3,) regulates antigen-induced eosinophll recruitment into the tissue, we studied the effect of recombinant (r) murine IFN-3, and of anti-IFN-3, monoclonal antibody (mAb) on the eosinophil infiltration of the trachea induced by antigen inhalation in mice. The intraperitoneal administration of rlFN-3, prevented antigen-induced eosinophil infiltration in the trachea of sensitized mice. The administration of rIFN-3, also decreased antigen-induced CD4 + T cell but not CD8 + T cell infiltration in the trachea. On the other hand, pretreatment with anti-IFN-'y mAb enhanced antigen-induced eosinophil and CD4 + T cell infiltration in the trachea. These results indicate that IFN-3, regulates antigen-induced eosinophil recruitment into the tissue by inhibiting CD4 + T cell infiltration.